Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms. The phytochemical investigation of the extracts led to the isolation of te...

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Dades bibliogràfiques
Publicat a:J Enzyme Inhib Med Chem
Autors principals: Fois, Benedetta, Distinto, Simona, Meleddu, Rita, Deplano, Serenella, Maccioni, Elias, Floris, Costantino, Rosa, Antonella, Nieddu, Mariella, Caboni, Pierluigi, Sissi, Claudia, Angeli, Andrea, Supuran, Claudiu T., Cottiglia, Filippo
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006766/
https://ncbi.nlm.nih.gov/pubmed/31948300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1713114
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