Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a–m) was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitory potency and selectivity toward human carbonic anhy...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Distinto, Simona, Meleddu, Rita, Ortuso, Francesco, Cottiglia, Filippo, Deplano, Serenella, Sequeira, Lisa, Melis, Claudia, Fois, Benedetta, Angeli, Andrea, Capasso, Clemente, Angius, Rossella, Alcaro, Stefano, Supuran, Claudiu T., Maccioni, Elias
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713091/
https://ncbi.nlm.nih.gov/pubmed/31431095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1654470
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