Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors

[Image: see text] A small library of psoralen carboxylic acids and their corresponding benzenesulfonamide derivatives were designed and synthesized to evaluate their activity and selectivity toward tumor associated human carbonic anhydrase (hCA) isoforms IX and XII. Both psoralen acids and sulfonami...

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Publicado en:ACS Med Chem Lett
Autores principales: Melis, Claudia, Distinto, Simona, Bianco, Giulia, Meleddu, Rita, Cottiglia, Filippo, Fois, Benedetta, Taverna, Domenico, Angius, Rossella, Alcaro, Stefano, Ortuso, Francesco, Gaspari, Marco, Angeli, Andrea, Del Prete, Sonia, Capasso, Clemente, Supuran, Claudiu T., Maccioni, Elias
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047168/
https://ncbi.nlm.nih.gov/pubmed/30034608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00170
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