Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors

[Image: see text] A small library of psoralen carboxylic acids and their corresponding benzenesulfonamide derivatives were designed and synthesized to evaluate their activity and selectivity toward tumor associated human carbonic anhydrase (hCA) isoforms IX and XII. Both psoralen acids and sulfonami...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Melis, Claudia, Distinto, Simona, Bianco, Giulia, Meleddu, Rita, Cottiglia, Filippo, Fois, Benedetta, Taverna, Domenico, Angius, Rossella, Alcaro, Stefano, Ortuso, Francesco, Gaspari, Marco, Angeli, Andrea, Del Prete, Sonia, Capasso, Clemente, Supuran, Claudiu T., Maccioni, Elias
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2018
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047168/
https://ncbi.nlm.nih.gov/pubmed/30034608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00170
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