Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

The non-conventional neurotrophic factor mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident protein that promotes ER homeostasis. MANF has a cytoprotective function, shown in the central nervous system neurons and pancreatic beta cells. Here, we repo...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Herranen, Anni, Ikäheimo, Kuu, Lankinen, Tuuli, Pakarinen, Emmi, Fritzsch, Bernd, Saarma, Mart, Lindahl, Maria, Pirvola, Ulla
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005028/
https://ncbi.nlm.nih.gov/pubmed/32029702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2286-6
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