Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation

We have studied the mechanisms of auditory hair cell death after insults in vitro and in vivo. We show DNA fragmentation of hair cell nuclei after ototoxic drug and intense noise trauma. By using phospho-specific c-Jun-N-terminal kinase (JNK) and c-Jun antibodies in immunohistochemistry, we show tha...

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Published in:J Neurosci
Main Authors: Pirvola, Ulla, Xing-Qun, Liang, Virkkala, Jussi, Saarma, Mart, Murakata, Chikara, Camoratto, Anna Marie, Walton, Kevin M., Ylikoski, Jukka
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774096/
https://ncbi.nlm.nih.gov/pubmed/10627579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-01-00043.2000
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