Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation

We have studied the mechanisms of auditory hair cell death after insults in vitro and in vivo. We show DNA fragmentation of hair cell nuclei after ototoxic drug and intense noise trauma. By using phospho-specific c-Jun-N-terminal kinase (JNK) and c-Jun antibodies in immunohistochemistry, we show tha...

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Publicado no:J Neurosci
Main Authors: Pirvola, Ulla, Xing-Qun, Liang, Virkkala, Jussi, Saarma, Mart, Murakata, Chikara, Camoratto, Anna Marie, Walton, Kevin M., Ylikoski, Jukka
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774096/
https://ncbi.nlm.nih.gov/pubmed/10627579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-01-00043.2000
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