Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

Neurons undergoing apoptosis can be rescued by trophic factors that simultaneously increase the activity of extracellular signal-regulated kinase (ERK) and decrease c-Jun N-terminal kinase (JNK) and p38. We identified a molecule, CEP-1347 (KT7515), that rescues motoneurons undergoing apoptosis and i...

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Publicado no:J Neurosci
Main Authors: Maroney, Anna C., Glicksman, Marcie A., Basma, Alie N., Walton, Kevin M., Knight, Ernest, Murphy, Carol A., Bartlett, Becky A., Finn, James P., Angeles, Thelma, Matsuda, Yuzuru, Neff, Nicola T., Dionne, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793399/
https://ncbi.nlm.nih.gov/pubmed/9412490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-01-00104.1998
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