Inhibition of the c-Jun N-Terminal Kinase Signaling Pathway by the Mixed Lineage Kinase Inhibitor CEP-1347 (KT7515) Preserves Metabolism and Growth of Trophic Factor-Deprived Neurons

Nerve growth factor (NGF) deprivation triggers metabolic changes in sympathetic neurons that precede cell death. Here, we investigate the role of the c-Jun N-terminal kinase (JNK) pathway in downregulating neuronal metabolism. We show that, in the presence of CEP-1347 (KT7515), a small molecule know...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Harris, Charles A., Deshmukh, Mohanish, Tsui-Pierchala, Brian, Maroney, Anna C., Johnson, Eugene M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757592/
https://ncbi.nlm.nih.gov/pubmed/11756493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-01-00103.2002
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