Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain

The tumor suppressor gene p53 encodes a transcriptional activator that has two transactivation domains (TAD) located in its amino terminus. These two TAD can transactivate genes independently, and at least one TAD is required for p53 transactivation function. The 1st TAD (a.a. 1‐40) is essential for...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Sci
Hauptverfasser: Suzuki, Shiori, Tsutsumi, Shuichi, Chen, Yu, Ozeki, Chikako, Okabe, Atsushi, Kawase, Tatsuya, Aburatani, Hiroyuki, Ohki, Rieko
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004532/
https://ncbi.nlm.nih.gov/pubmed/31834974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14279
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