PHLDA1, another PHLDA family protein that inhibits Akt

The PHLDA family (pleckstrin homology‐like domain family) of genes consists of 3 members: PHLDA1, 2, and 3. Both PHLDA3 and PHLDA2 are phosphatidylinositol (PIP) binding proteins and function as repressors of Akt. They have tumor suppressive functions, mainly through Akt inhibition. Several reports...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Chen, Yu, Takikawa, Masahiro, Tsutsumi, Shuichi, Yamaguchi, Yoko, Okabe, Atsushi, Shimada, Mayuna, Kawase, Tatsuya, Sada, Akane, Ezawa, Issei, Takano, Yuhei, Nagata, Kisaburo, Suzuki, Yutaka, Semba, Kentaro, Aburatani, Hiroyuki, Ohki, Rieko
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215895/
https://ncbi.nlm.nih.gov/pubmed/30207029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13796
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