IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

The transcription factors HSF1 and p53 both modulate the stress response, thereby protecting and facilitating the recovery of stressed cells, but both have the potential to promote tumor development. Here we show that a p53 target gene, IER5, encodes an activator of HSF1. IER5 forms a ternary comple...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Asano, Yoshinori, Kawase, Tatsuya, Okabe, Atsushi, Tsutsumi, Shuichi, Ichikawa, Hitoshi, Tatebe, Satoko, Kitabayashi, Issay, Tashiro, Fumio, Namiki, Hideo, Kondo, Tadashi, Semba, Kentaro, Aburatani, Hiroyuki, Taya, Yoichi, Nakagama, Hitoshi, Ohki, Rieko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709660/
https://ncbi.nlm.nih.gov/pubmed/26754925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19174
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