IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

The transcription factors HSF1 and p53 both modulate the stress response, thereby protecting and facilitating the recovery of stressed cells, but both have the potential to promote tumor development. Here we show that a p53 target gene, IER5, encodes an activator of HSF1. IER5 forms a ternary comple...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Asano, Yoshinori, Kawase, Tatsuya, Okabe, Atsushi, Tsutsumi, Shuichi, Ichikawa, Hitoshi, Tatebe, Satoko, Kitabayashi, Issay, Tashiro, Fumio, Namiki, Hideo, Kondo, Tadashi, Semba, Kentaro, Aburatani, Hiroyuki, Taya, Yoichi, Nakagama, Hitoshi, Ohki, Rieko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709660/
https://ncbi.nlm.nih.gov/pubmed/26754925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19174
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados