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IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis
The transcription factors HSF1 and p53 both modulate the stress response, thereby protecting and facilitating the recovery of stressed cells, but both have the potential to promote tumor development. Here we show that a p53 target gene, IER5, encodes an activator of HSF1. IER5 forms a ternary comple...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4709660/ https://ncbi.nlm.nih.gov/pubmed/26754925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19174 |
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