Cancer Susceptibility Polymorphism of p53 at Codon 72 Affects Phosphorylation and Degradation of p53 Protein

The common polymorphism of p53 at codon 72, either encoding proline or arginine, has drawn attention as a genetic factor associated with clinical outcome or cancer risk for the last 2 decades. We now show that these two polymorphic variants differ in protein structure, especially within the N-termin...

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Main Authors: Ozeki, Chikako, Sawai, Yuichiro, Shibata, Tatsuhiro, Kohno, Takashi, Okamoto, Koji, Yokota, Jun, Tashiro, Fumio, Tanuma, Sei-ichi, Sakai, Ryuichi, Kawase, Tatsuya, Kitabayashi, Issay, Taya, Yoichi, Ohki, Rieko
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093897/
https://ncbi.nlm.nih.gov/pubmed/21454683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208587
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