Cancer Susceptibility Polymorphism of p53 at Codon 72 Affects Phosphorylation and Degradation of p53 Protein

The common polymorphism of p53 at codon 72, either encoding proline or arginine, has drawn attention as a genetic factor associated with clinical outcome or cancer risk for the last 2 decades. We now show that these two polymorphic variants differ in protein structure, especially within the N-termin...

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Detalhes bibliográficos
Main Authors: Ozeki, Chikako, Sawai, Yuichiro, Shibata, Tatsuhiro, Kohno, Takashi, Okamoto, Koji, Yokota, Jun, Tashiro, Fumio, Tanuma, Sei-ichi, Sakai, Ryuichi, Kawase, Tatsuya, Kitabayashi, Issay, Taya, Yoichi, Ohki, Rieko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093897/
https://ncbi.nlm.nih.gov/pubmed/21454683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208587
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