Cancer Susceptibility Polymorphism of p53 at Codon 72 Affects Phosphorylation and Degradation of p53 Protein

The common polymorphism of p53 at codon 72, either encoding proline or arginine, has drawn attention as a genetic factor associated with clinical outcome or cancer risk for the last 2 decades. We now show that these two polymorphic variants differ in protein structure, especially within the N-termin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ozeki, Chikako, Sawai, Yuichiro, Shibata, Tatsuhiro, Kohno, Takashi, Okamoto, Koji, Yokota, Jun, Tashiro, Fumio, Tanuma, Sei-ichi, Sakai, Ryuichi, Kawase, Tatsuya, Kitabayashi, Issay, Taya, Yoichi, Ohki, Rieko
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093897/
https://ncbi.nlm.nih.gov/pubmed/21454683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208587
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