TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects

Tumor necrosis factor alpha (TNF) is capable of inducing regression of solid tumors. However, TNF released in response to Toll-like receptor 4 (TLR4) activation by bacterial lipopolysaccharide (LPS) is the key mediator of cytokine storm and septic shock that can cause severe tissue damage limiting a...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Haderski, Gary J., Kandar, Bojidar M., Brackett, Craig M., Toshkov, Ilia M., Johnson, Christopher P., Paszkiewicz, Geraldine M., Natarajan, Venkatesh, Gleiberman, Anatoli S., Gudkov, Andrei V., Burdelya, Lyudmila G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004342/
https://ncbi.nlm.nih.gov/pubmed/32027657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227940
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