Acyldepsipeptide Probes Facilitate Specific Detection of Caseinolytic Protease P Independent of Its Oligomeric and Activity State

Caseinolytic protease P (ClpP) is a tetradecameric peptidase that assembles with chaperones such as ClpX to gain proteolytic activity. Acyldepsipeptides (ADEPs) are small‐molecule mimics of ClpX that bind into hydrophobic pockets on the apical site of the complex, thereby activating ClpP. Detection...

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Bibliographic Details
Published in:Chembiochem
Main Authors: Eyermann, Barbara, Meixner, Maximilian, Brötz‐Oesterhelt, Heike, Antes, Iris, Sieber, Stephan A.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003903/
https://ncbi.nlm.nih.gov/pubmed/31487112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900477
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