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Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential

Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was observed that natural product-derived acyldepsipept...

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Vydáno v:Front Mol Biosci
Hlavní autoři: Brötz-Oesterhelt, Heike, Vorbach, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8182300/
https://ncbi.nlm.nih.gov/pubmed/34109219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.690902
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