The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor

The increasing threat posed by multiresistant bacterial pathogens necessitates the discovery of novel antibacterials with unprecedented modes of action. ADEP1, a natural compound produced by Streptomyces hawaiiensis NRRL 15010, is the prototype for a new class of acyldepsipeptide (ADEP) antibiotics....

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Thomy, Dhana, Culp, Elizabeth, Adamek, Martina, Cheng, Eric Y., Ziemert, Nadine, Wright, Gerard D., Sass, Peter, Brötz-Oesterhelt, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Environmental Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805094/
https://ncbi.nlm.nih.gov/pubmed/31399403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01292-19
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