The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor

The increasing threat posed by multiresistant bacterial pathogens necessitates the discovery of novel antibacterials with unprecedented modes of action. ADEP1, a natural compound produced by Streptomyces hawaiiensis NRRL 15010, is the prototype for a new class of acyldepsipeptide (ADEP) antibiotics....

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Vydáno v:Appl Environ Microbiol
Hlavní autoři: Thomy, Dhana, Culp, Elizabeth, Adamek, Martina, Cheng, Eric Y., Ziemert, Nadine, Wright, Gerard D., Sass, Peter, Brötz-Oesterhelt, Heike
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Environmental Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805094/
https://ncbi.nlm.nih.gov/pubmed/31399403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01292-19
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