N‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

Herein, the application of N‐hydroxysuccinimide‐modified phosphonamidate building blocks for the incorporation of cysteine‐selective ethynylphosphonamidates into lysine residues of proteins, followed by thiol addition with small molecules and proteins, is reported. It is demonstrated that the buildi...

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Publicado en:Chembiochem
Main Authors: Kasper, Marc‐André, Gerlach, Marcus, Schneider, Anselm F. L., Groneberg, Christiane, Ochtrop, Philipp, Boldt, Stefanie, Schumacher, Dominik, Helma, Jonas, Leonhardt, Heinrich, Christmann, Mathias, Hackenberger, Christian P. R.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003776/
https://ncbi.nlm.nih.gov/pubmed/31661184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900587
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