N‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

Herein, the application of N‐hydroxysuccinimide‐modified phosphonamidate building blocks for the incorporation of cysteine‐selective ethynylphosphonamidates into lysine residues of proteins, followed by thiol addition with small molecules and proteins, is reported. It is demonstrated that the buildi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chembiochem
Prif Awduron: Kasper, Marc‐André, Gerlach, Marcus, Schneider, Anselm F. L., Groneberg, Christiane, Ochtrop, Philipp, Boldt, Stefanie, Schumacher, Dominik, Helma, Jonas, Leonhardt, Heinrich, Christmann, Mathias, Hackenberger, Christian P. R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Full Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003776/
https://ncbi.nlm.nih.gov/pubmed/31661184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900587
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