Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates

Requirements for novel bioconjugation reactions for the synthesis of antibody–drug conjugates (ADCs) are exceptionally high, since conjugation selectivity as well as the stability and hydrophobicity of linkers and payloads drastically influence the performance and safety profile of the final product...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Kasper, Marc‐André, Stengl, Andreas, Ochtrop, Philipp, Gerlach, Marcus, Stoschek, Tina, Schumacher, Dominik, Helma, Jonas, Penkert, Martin, Krause, Eberhard, Leonhardt, Heinrich, Hackenberger, Christian P. R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851832/
https://ncbi.nlm.nih.gov/pubmed/31250955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201904193
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