Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates

Requirements for novel bioconjugation reactions for the synthesis of antibody–drug conjugates (ADCs) are exceptionally high, since conjugation selectivity as well as the stability and hydrophobicity of linkers and payloads drastically influence the performance and safety profile of the final product...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Kasper, Marc‐André, Stengl, Andreas, Ochtrop, Philipp, Gerlach, Marcus, Stoschek, Tina, Schumacher, Dominik, Helma, Jonas, Penkert, Martin, Krause, Eberhard, Leonhardt, Heinrich, Hackenberger, Christian P. R.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851832/
https://ncbi.nlm.nih.gov/pubmed/31250955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201904193
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