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Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213
The role of Phe213 in the allosteric mechanism of human cytochrome P450 CYP3A4 was studied using a combination of progesterone (PGS) and carbamazepine (CBZ) as probe substrates. We expressed, purified and incorporated in POPC Nanodiscs three mutants, F213A, F213S, and F213Y, and compared them with t...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7003538/ https://ncbi.nlm.nih.gov/pubmed/30785734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01268 |
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