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The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4
Cytochrome P450 CYP3A4 is the main drug-metabolizing enzyme in the human liver, being responsible for oxidation of ~ 50% of all pharmaceuticals metabolized by human P450 enzymes. Possessing a relatively large substrate-binding pocket, it can simultaneously bind several substrate molecules and thus o...
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| Publié dans: | J Inorg Biochem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887402/ https://ncbi.nlm.nih.gov/pubmed/26774838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2015.12.019 |
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