The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4

Cytochrome P450 CYP3A4 is the main drug-metabolizing enzyme in the human liver, being responsible for oxidation of ~ 50% of all pharmaceuticals metabolized by human P450 enzymes. Possessing a relatively large substrate-binding pocket, it can simultaneously bind several substrate molecules and thus o...

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Bibliografiske detaljer
Udgivet i:J Inorg Biochem
Main Authors: Denisov, Ilia G., Mak, Piotr J., Grinkova, Yelena V., Bastien, Dominic, Bérubé, Gervais, Sligar, Stephen G., Kincaid, James R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887402/
https://ncbi.nlm.nih.gov/pubmed/26774838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2015.12.019
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