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Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain

Prions are pathological isoforms of the cellular prion protein that is responsible for transmissible spongiform encephalopathies (TSE). Cellular prion protein interacts with copper, Cu(II), through octarepeat and nonoctarepeat (non-OR) binding sites. The molecular details of Cu(II) coordination with...

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Bibliografische gegevens
Gepubliceerd in:Biophys J
Hoofdauteurs: Salzano, Giulia, Brennich, Martha, Mancini, Giordano, Tran, Thanh Hoa, Legname, Giuseppe, D’Angelo, Paola, Giachin, Gabriele
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002980/
https://ncbi.nlm.nih.gov/pubmed/31952810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.12.025
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