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The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion
The conversion of the prion protein (PrP(C)) into prions plays a key role in transmissible spongiform encephalopathies. Despite the importance for pathogenesis, the mechanism of prion formation has escaped detailed characterization due to the insoluble nature of prions. PrP(C) interacts with copper...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4651146/ https://ncbi.nlm.nih.gov/pubmed/26482532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15253 |
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