The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion

The conversion of the prion protein (PrP(C)) into prions plays a key role in transmissible spongiform encephalopathies. Despite the importance for pathogenesis, the mechanism of prion formation has escaped detailed characterization due to the insoluble nature of prions. PrP(C) interacts with copper...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Giachin, Gabriele, Mai, Phuong Thao, Tran, Thanh Hoa, Salzano, Giulia, Benetti, Federico, Migliorati, Valentina, Arcovito, Alessandro, Longa, Stefano Della, Mancini, Giordano, D’Angelo, Paola, Legname, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651146/
https://ncbi.nlm.nih.gov/pubmed/26482532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15253
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