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mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion

How activated B cells build biosynthetic pathways and organelle structures necessary for subsequent robust antibody secretion is still unclear. The dominant model holds that nascent plasma cells adapt to increased antibody synthesis by activating the unfolded protein response (UPR) under the control...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Gaudette, Brian T., Jones, Derek D., Bortnick, Alexandra, Argon, Yair, Allman, David
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002553/
https://ncbi.nlm.nih.gov/pubmed/32024827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14032-1
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