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Can BDDCS Illuminate Targets in Drug Design?

The fact that pharmacokinetic (PK) properties of drugs influence the interaction with protein targets is a principle known for decades. The same cannot be said for the opposite – namely that targets influence PK properties of drugs. Evidence confirming this possibility is first introduced here, as w...

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Bibliografiske detaljer
Udgivet i:Drug Discov Today
Main Authors: Bocci, Giovanni, Benet, Leslie Z., Oprea, Tudor I.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002033/
https://ncbi.nlm.nih.gov/pubmed/31585170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2019.09.021
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