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Improving the prediction of the brain disposition for orally administered drugs using BDDCS
In modeling blood–brain barrier (BBB) passage, in silico models have yielded ~80% prediction accuracy, and are currently used in early drug discovery. Being derived from molecular structural information only, these models do not take into account the biological factors responsible for the in vivo ou...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3496430/ https://ncbi.nlm.nih.gov/pubmed/22261306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2011.12.008 |
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