Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1

The Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in tumorigenesis by regulating protein homeostasis in response to stress. Thus, simultaneous inhibition of all Hsp90 paralogs is a reas...

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Vydáno v:Exp Mol Med
Hlavní autoři: Park, Hye-Kyung, Yoon, Nam Gu, Lee, Ji-Eun, Hu, Sung, Yoon, Sora, Kim, So Yeon, Hong, Jun-Hee, Nam, Dougu, Chae, Young Chan, Park, Jong Bae, Kang, Byoung Heon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000702/
https://ncbi.nlm.nih.gov/pubmed/31956271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0360-x
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