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Conformational cycling within the closed state of Grp94, an Hsp90-family chaperone

The Hsp90 family of chaperones require ATP-driven cycling to perform their function. The presence of two bound ATP molecules is known to favor a closed conformation of the Hsp90 dimer. However, the structural and mechanistic consequences of subsequent ATP hydrolysis are poorly understood. Using sing...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Biol
Prif Awduron: Huang, Bin, Friedman, Larry J., Sun, Ming, Gelles, Jeff, Street, Timothy O.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697201/
https://ncbi.nlm.nih.gov/pubmed/31202885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.06.004
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