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Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling

Aberrantly high mTORC1 signaling is a known driver of many cancers and human disorders, yet pharmacological inhibition of mTORC1 rarely confers durable clinical responses. To explore alternative therapeutic strategies, herein we conducted a proteomics survey to identify cell surface proteins upregul...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Wei, Junnian, Leung, Kevin, Truillet, Charles, Ruggero, Davide, Wells, James A., Evans, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000124/
https://ncbi.nlm.nih.gov/pubmed/31792071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001785
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