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Tracing the Origin and Evolution of Pseudokinases Across the Tree of Life

Protein phosphorylation by eukaryotic protein kinases (ePKs) represents a fundamental mechanism of cell signaling in all organisms. In model vertebrates, ~10% of ePKs are classified as pseudokinases, which possess amino acid changes within the catalytic machinery of the kinase domain that distinguis...

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Foilsithe in:Sci Signal
Main Authors: Kwon, Annie, Scott, Steven, Taujale, Rahil, Yeung, Wayland, Kochut, Krys J., Eyers, Patrick A., Kannan, Natarajan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997932/
https://ncbi.nlm.nih.gov/pubmed/31015289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav3810
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