Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

A major challenge associated with biochemical and cellular analysis of pseudokinases is a lack of target-validated small-molecule compounds with which to probe function. Tribbles 2 (TRIB2) is a cancer-associated pseudokinase with a diverse interactome, including the canonical AKT signaling module. T...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Sci Signal
Main Authors: Foulkes, Daniel M., Byrne, Dominic P., Yeung, Wayland, Shrestha, Safal, Bailey, Fiona P., Ferries, Samantha, Eyers, Claire E., Keeshan, Karen, Wells, Carrow, Drewry, David H., Zuercher, William J., Kannan, Natarajan, Eyers, Patrick A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553640/
https://ncbi.nlm.nih.gov/pubmed/30254057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat7951
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares