Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

A major challenge associated with biochemical and cellular analysis of pseudokinases is a lack of target-validated small-molecule compounds with which to probe function. Tribbles 2 (TRIB2) is a cancer-associated pseudokinase with a diverse interactome, including the canonical AKT signaling module. T...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Foulkes, Daniel M., Byrne, Dominic P., Yeung, Wayland, Shrestha, Safal, Bailey, Fiona P., Ferries, Samantha, Eyers, Claire E., Keeshan, Karen, Wells, Carrow, Drewry, David H., Zuercher, William J., Kannan, Natarajan, Eyers, Patrick A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553640/
https://ncbi.nlm.nih.gov/pubmed/30254057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat7951
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