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PTEN Mouse Models of Cancer Initiation and Progression

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is one of the most frequently mutated, deleted, and functionally inactivated tumor suppressor genes in human cancer. PTEN is found mutated both somatically and in the germline of patients with PTEN hamartoma tumor syndrome (PHTS). PTEN e...

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Pubblicato in:Cold Spring Harb Perspect Med
Autori principali: Lee, Yu-Ru, Pandolfi, Pier Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996448/
https://ncbi.nlm.nih.gov/pubmed/31570383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a037283
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