WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition

BACKGROUND: Patients with PTEN hamartoma tumor syndrome (PHTS) have germline mutations in the tumor-suppressor gene encoding phosphatase and tensin homologue (PTEN). Such mutations have been associated with a hereditary predisposition to multiple types of cancer, including the Cowden syndrome. Howev...

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Udgivet i:N Engl J Med
Main Authors: Lee, Yu-Ru, Yehia, Lamis, Kishikawa, Takahiro, Ni, Ying, Leach, Brandie, Zhang, Jinfang, Panch, Nivedita, Liu, Jing, Wei, Wenyi, Eng, Charis, Pandolfi, Pier Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839065/
https://ncbi.nlm.nih.gov/pubmed/32459922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1914919
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