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PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer
Inactivation and silencing of PTEN have been observed in multiple cancers, including follicular thyroid carcinoma. PTEN (phosphatase and tensin homologue deleted from chromosome 10) functions as a tumour suppressor by opposing the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signallin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3457778/ https://ncbi.nlm.nih.gov/pubmed/18997818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.407 |
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