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Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors

Correlative data suggest that thyroid hormone receptor-β (TRβ) mutations could increase the risk of mammary tumor development, but unequivocal evidence is still lacking. To explore the role of TRβ mutants in vivo in breast tumor development and progression, we took advantage of a knock-in mouse mode...

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Bibliographic Details
Main Authors: Guigon, CJ, Kim, DW, Willingham, MC, Cheng, S-y
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457781/
https://ncbi.nlm.nih.gov/pubmed/21399657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.50
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