Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription

Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer (CRC), however, remains unclear. Here we demonstrate that menin was overexpressed in CRC and that inhibition of menin synergized with sma...

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Publicado en:Cancer Res
Autores principales: Katona, Bryson W., Glynn, Rebecca A., Paulosky, Kayla E., Feng, Zijie, Davis, Caroline I., Ma, Jian, Berry, Corbett T., Szigety, Katherine M., Matkar, Smita, Liu, Yuanyuan, Wang, Haoren, Wu, Yuan, He, Xin, Freedman, Bruce D., Brady, Donita C., Hua, Xianxin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996413/
https://ncbi.nlm.nih.gov/pubmed/30877106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2133
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