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Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription

Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer (CRC), however, remains unclear. Here we demonstrate that menin was overexpressed in CRC and that inhibition of menin synergized with sma...

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Bibliografske podrobnosti
izdano v:	Cancer Res
Main Authors:	Katona, Bryson W., Glynn, Rebecca A., Paulosky, Kayla E., Feng, Zijie, Davis, Caroline I., Ma, Jian, Berry, Corbett T., Szigety, Katherine M., Matkar, Smita, Liu, Yuanyuan, Wang, Haoren, Wu, Yuan, He, Xin, Freedman, Bruce D., Brady, Donita C., Hua, Xianxin
Format:	Artigo
Jezik:	Inglês
Izdano:	2019
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6996413/ https://ncbi.nlm.nih.gov/pubmed/30877106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2133
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Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription

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