Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion. There is preferential loss of medium spiny neurons within the striatum and cortical pyramidal neurons. Pridopid...

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Udgivet i:Neurobiol Dis
Main Authors: Eddings, Chelsy R., Arbez, Nicolas, Akimov, Sergey, Geva, Michal, Hayden, Michael R., Ross, Christopher A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996243/
https://ncbi.nlm.nih.gov/pubmed/31108174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.05.009
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