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Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor
Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion. There is preferential loss of medium spiny neurons within the striatum and cortical pyramidal neurons. Pridopid...
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| Publicado no: | Neurobiol Dis |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996243/ https://ncbi.nlm.nih.gov/pubmed/31108174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.05.009 |
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