The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium spiny neurons (MSNs). HD is a devastating autosomal dominant disease with no disease-modifying treatments. Pridopidine, a postula...

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Detaylı Bibliyografya
Yayımlandı:Neurobiol Dis
Asıl Yazarlar: Ryskamp, Daniel, Wu, Jun, Geva, Michal, Kusko, Rebecca, Grossman, Iris, Hayden, Michael, Bezprozvanny, Ilya
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214572/
https://ncbi.nlm.nih.gov/pubmed/27818324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.10.006
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