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The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease
The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium spiny neurons (MSNs). HD is a devastating autosomal dominant disease with no disease-modifying treatments. Pridopidine, a postula...
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| Publié dans: | Neurobiol Dis |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5214572/ https://ncbi.nlm.nih.gov/pubmed/27818324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.10.006 |
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