Pridopidine stabilizes mushroom spines in mouse models of Alzheimer’s disease by acting on the sigma-1 receptor

There is evidence that cognitive decline in Alzheimer’s disease (AD) results from deficiencies in synaptic communication (e.g., loss of mushroom-shaped ‘memory spines’) and neurodegenerative processes. This might be treated with sigma-1 receptor (S1R) agonists, which are broadly neuroprotective and...

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Detaylı Bibliyografya
Yayımlandı:Neurobiol Dis
Asıl Yazarlar: Ryskamp, Daniel, Wu, Lili, Wu, Jun, Kim, Dabin, Rammes, Gerhard, Geva, Michal, Hayden, Michael, Bezprozvanny, Ilya
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363865/
https://ncbi.nlm.nih.gov/pubmed/30594810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.12.022
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