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Pridopidine stabilizes mushroom spines in mouse models of Alzheimer’s disease by acting on the sigma-1 receptor
There is evidence that cognitive decline in Alzheimer’s disease (AD) results from deficiencies in synaptic communication (e.g., loss of mushroom-shaped ‘memory spines’) and neurodegenerative processes. This might be treated with sigma-1 receptor (S1R) agonists, which are broadly neuroprotective and...
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| Publicat a: | Neurobiol Dis |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363865/ https://ncbi.nlm.nih.gov/pubmed/30594810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.12.022 |
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