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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP(3))-Dependent Rac Exchanger 1 (P-Rex1) PIP(3)-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils
Phosphatidylinositol (3,4,5) trisphosphate (PIP(3))-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally discovered in neutrophils and is regulated by G protein βγ subunits and the lipid PIP(3) in response to chemoattractants. P-Rex1 has also become incr...
Tallennettuna:
| Julkaisussa: | Mol Pharmacol |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The American Society for Pharmacology and Experimental Therapeutics
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6994817/ https://ncbi.nlm.nih.gov/pubmed/31900312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117556 |
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