Upregulation of PIP3-Dependent Rac Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis

Excessive activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) pathways has been linked to prostate cancer metastasis. Rac activation by guanine-nucleotide exchange factors (GEFs) plays an important role in directional cell migration, a critical step of tumor metastasis...

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Bibliographic Details
Main Authors: Qin, Jianbing, Xie, Yan, Wang, Bo, Hoshino, Mikio, Wolff, Dennis W., Zhao, Jing, Scofield, Margaret A., Dowd, Frank J., Lin, Ming-Fong, Tu, Yaping
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672965/
https://ncbi.nlm.nih.gov/pubmed/19305425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.30
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