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Structural and biochemical characterization of the catalytic core of the metastatic factor P-Rex1 and its regulation by PtdIns(3,4,5)P(3)
Phosphatidylinositol 3,4,5-trisphosphate (PIP(3))-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine nucleotide exchange factor synergistically activated by PIP(3) and Gβγ that plays an important role in the metastasis of breast, prostate, and skin cancer, making it an attractive therapeutic target...
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| Publicado no: | Structure |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860252/ https://ncbi.nlm.nih.gov/pubmed/27150042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.02.022 |
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