Human autologous iPSC–derived dopaminergic progenitors restore motor function in Parkinson’s disease models

Parkinson’s disease (PD) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy. To establish human induced pluripotent stem cell–...

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Pubblicato in:J Clin Invest
Autori principali: Song, Bin, Cha, Young, Ko, Sanghyeok, Jeon, Jeha, Lee, Nayeon, Seo, Hyemyung, Park, Kyung-Joon, Lee, In-Hee, Lopes, Claudia, Feitosa, Melissa, Luna, María José, Jung, Jin Hyuk, Kim, Jisun, Hwang, Dabin, Cohen, Bruce M., Teicher, Martin H., Leblanc, Pierre, Carter, Bob S., Kordower, Jeffrey H., Bolshakov, Vadim Y., Kong, Sek Won, Schweitzer, Jeffrey S., Kim, Kwang-Soo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994130/
https://ncbi.nlm.nih.gov/pubmed/31714896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130767
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